Linear 1 3-diarylpropanoids

Organic compounds contain a central propyl group (3 carbon chain) with one phenyl group bonded to the first and the third carbons in the propyl chain; the propyl chain may contain other functional groups, such as a carbon - carbon double bond.

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691 – 705 of 719 results

691

Medchemexpress LLC Phlorizin | 60-81-1 | MFCD00006652 | ≥98% | 436.43 | 1 G

Phlorizin is a biochemical reagent that acts as a non-selective SGLT inhibitor (hSGLT1 Ki: 300 nM, hSGLT2 Ki: 39 nM) and a Na+/K+-ATPase inhibitor. It is suitable for use as a biological material or organic compound in life science research.

Non-selective SGLT inhibitor
Na+/K+-ATPase inhibitor
Classification: Flavonoids, Phenols, Polyphenols, Dihydrochalcones
Source: Malus pumila Mill. (Rosaceae), Plants
Targets: SGLT, Na+/K+ ATPase
Research areas: Metabolic disease

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692

AdipoGen Phloretin

Chemical. CAS 60-82-2. Formula C15H14O5. MW 274.27. Phloretin is a natural dihydrochalcone, originally identified from the apple tree, and is a metabolite of phlorizin. It has numerous pharmacological effects, including anti-inflammatory, antidiabetic, anticancer, antimicrobial, hepatoprotective, neuroprotective and cytoprotective properties. Phloretin is a potent antioxidant, scavenging peroxynitrite ONOO- and/or suppressing lipid peroxidation, which contributes to the many biological properties. Phloretin has anti-aging and depigmenting effects, making it also attractive for dermatological research and application. Phloretin attacks a number of molecular targets, modulating different intracellular signaling pathways, including NF-kappaB, MAPK, Nrf2, and AMPK. It can modulate Ca2 channels, PKC, GLUTs, SGLTs and other targets. The anticancer potential is based on antiproliferative, proapoptotic, antimetastatic, and antiangiogenic activities.